Tramadol Vs Oxycodone
Tramadol Vs Oxycodone

5 Tramadol Vs Oxycodone, Which One is Better?

A long time ago during the Stone Age, people believed that pain came as an unluckiness, unfortunates, and a punishment from The Spirits and Gods they believed. That is why they would offer sacrifice to endure or eliminate the pain with animals or even human-soul. Later on, they found natural painkillers from plants.

Those natural painkillers led modern people to find a new formula for pain relievers. Scientists successfully formed modern painkillers we know nowadays in the 19th century, such as Tramadol Vs Oxycodone. Lucky us that we lived in the 20th century, when we can do dental repairs, surgery, and tooth extraction without feeling the pain because of the painkillers.

Three main pain relievers are mostly used by patients to endure their pain. They are paracetamol, non-steroidal anti-inflammatory drugs (NSAIDs), and opioids. Each of these pain relievers work differently and most patients will need to take this for a few days. But some people who suffer some serious pains need to take a painkiller for a long time.

Some painkillers can be got without prescriptions and some others need doctor prescriptions. For instance, Tramadol and Oxycodone, if you want to buy one of those painkillers, then you need your doctor’s prescriptions.

How Tramadol Vs Oxycodone Are Different from Each Other?

Painkillers are drugs or medicines that are used to eliminate, treat and endure pain. The painkillers can be taken by tablets, injections, capsules, or liquids. Most popular painkillers for instance Tramadol and Oxycodone which need a doctor prescribes to get.

These painkillers are mostly used to eliminate moderate up to severe pain. The class of drugs they belong to are opioid analgesics. It means that they work in the brain and change the transmission so that the body will be unable to feel the pain. Doctors usually will give these drugs to you and they will inform you what you can expect from the treatment.

Doctors will give you the right treatment with lots of considerations. If you are curious about these painkillers; Tramadol and Oxycodone, you are on the right page already. In this article, you will find out what makes these two painkillers are different.


Oxycodone is a generic drug that is synthesized from a part of opi**um poppy plant called thebaine. According to FDA or Food and Drug Administration of the US, this painkiller is classified as a Schedule II drug. Oxycodone is approved by FDA in 1976.

Schedule II drug means this drug is used for medical treatment, but its abuse may lead the patients to suffer some physical and psychological dependence. This painkiller works by decreasing the discomfort sensation of the pain so that the body tolerates the pain better. 

Meanwhile, Tramadol is a human-made analgesic painkiller and it is not NSAIDS or narco**tic medication. This painkiller is classified as a Schedule IV drug which means that it has lower risk and lower potential for abuse physical and psychological dependence.

Even though the exact action mechanism is not yet established, but many doctors believe that Tramadol works by binding the brain receptors which are transmitting the pain sensation. This way will make the body able to tolerate the pain. Tramadol is approved by FDA in 1995.


Oxycodone is a prescribed painkiller that is used to manage the sensation of pain. This painkiller can be used to moderate to severe pain, spontaneous pain, injury, and trauma. It also can be used for neurological pain such as shingles and chronic pain because of chronic medicine, for instance, bole pain and cancer pain.

Meanwhile, Tramadol is also used to treat the sensation of pain which ranges from moderate up to severe pain. You must take this painkiller with a prescription and you must not take this longer than the prescription. This also has proven to be beneficial to manage chronic pain.

Even though Tramadol has the lower potential abuse for physical and psychological dependence than Oxycodone, both painkillers are still potentially habit-forming. Especially for those suffering from drug addiction.


Doctors will usually give the dosage of Oxycodone to the patient based on the patient’s condition because all individuals have their conditions. If you have never had opioids before, the doctor usually will give you the lowest dosage between 5mg-15mg every 4 to 6 hours. Some others will be given 5mg-30mg, and others will get 30mg every 4 hours or more.

On the other hand, Tramadol is usually given starting from 25mg per day and later, the dosage may be increased to 25mg-50mg per day. Then, if the reaction is going well, the doctor will increase the dosage up to 50mg-100mg every 4 to 6 hours. The maximum dose of Tramadol is 400mg per day.

Side effects

Besides in addition to healing, the medicines we take also have inevitable side effects. Both Tramadol Vs Oxycodone have the same common side effects such as nausea, constipation, vomiting, headache, itching, drowsiness, and lack of energy

Furthermore, both of these painkillers sometimes give some serious side effects such as trouble breathing, anxiety, insomnia, and allergic reactions, for instance: hives, itching, swelling face, lips, and tongue. For the long-term used, both Tramadol and Oxycodone cause physical and psychological dependence.

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Other drug interaction

Most prescribed drugs have interaction with other drugs. Interaction is when there are substantial changes in the way a drug should work. This may be very harmful because it might prevent the drug to work well. Both Oxycodone and Tramadol have interaction with other painkillers such as fentanyl, mor**phine, and hydrocodone.

Some drugs that are used to cure serious mental disorders, for instance; prochlorperazine and chlorpromazine also have interaction with both Oxycodone and Tramadol. Other medicines such as quinidine, ketoconazole, erythromycin, amitriptyline, tranylcypromine, phenelzine, duloxetine, venlafaxine, paroxetine, fluoxetine, and other painkillers are interacting with Oxycodone and Tramadol as well.

Due to the interaction between Tramadol Vs Oxycodone and many other painkillers, make sure to consult your doctor first before taking Tramadol and Oxycodone.

Last Updated on September 7, 2021 Reviewed by Market Health Beauty Team