Xarelto Side Effects
Xarelto Side Effects

Xarelto Side Effects, Function, Warnings, and Doses

Xarelto is an anticoagulant drug to prevent blood clots. Understand the Xarelto side effects, its function, dosage, and how to use it in this discussion.

What is Xarelto?

Xarelto is a medicinal preparation containing the active substance, Rivaroxaban. Xarelto is used to help prevent blood clots due to irregular heartbeat (atrial fibrillation) or after replacement hip or knee surgery. Xarelto is also used to cure blood clots (as in DVT or Pulmonary Embolism), and prevent blood clots. Xarelto is an anticoagulant that works by blocking certain clotting proteins in the blood.

Xarelto Description

  • Class: Hard Drugs
  • Therapeutic Class: Anticoagulant, Antiplatelet, and Fibrinolytic (Thrombolytic)
  • Content: Rivaroxaban 10 mg; Rivaroxaban 15 mg; Rivaroxaban 20 mg
  • Form: Membrane-Coated Tablet
  • Unit of Sale: Blister
  • Packaging: Blister @ 14 Membrane-Coated Tablets
  • Pharmaceuticals: Bayer New Zealand

Xarelto function

Xarelto is an anticoagulant drug to prevent blood clots in several conditions, including:

  • Venous thromboembolism in older patients after hip or knee replacement surgery.
  • Prevents the risk of stroke.
  • Reduces the risk of systemic embolism in patients with nonvalvular atrial fibrillation.
  • Patients with pulmonary embolism.
  • Vascular and heart problems.

The doctor may prescribe this medication for other conditions related to the prevention of blood clots that are at risk of fatality to the patient’s health.

Xarelto warnings

Please pay attention to some of the following drug warnings:

  • Tell your doctor all the medications you’re currently using.
  • Do not share the drug with other patients even though they may have similar symptoms.
  • Stopping using this drug can suddenly provoke blood clots and the risk of stroke, so please consult a doctor before stopping the dosage.
  • Increases the risk of bleeding or active blood dilution.
  • Not recommended for patients with artificial heart valves.
  • Increases the risk of hemorrhagic or organ bleeding when the patient has a history of bleeding disorders.
  • This drug can affect the ability to use heavy machinery or drive, so it is best to avoid such activities after taking this drug.
  • Not recommended for patients with CrCl <15 mL / min.
  • Consultation with the doctor about xarelto side effects, dosage, and other medical advice during treatment with this drug.

The doctor will monitor the patient’s condition from time to time during the taking of this drug and periodically check his overall health.

Xarelto Dose and How To Use It

Dosage is a dose expressed in units of weight or volume (e.g. mg, gr) of health products (drugs, supplements, etc.) that must be used for a particular medical condition and the frequency of its administration. Usually the strength of this dosage depends on the medical condition, age, and weight of a person. The rules of use refer to how such health products are used or consumed.

Here are the dosages and rules of use of Xarelto:

Prevention of VTE in older persons undergoing pelvic or knee bone replacement surgery: 10 mg once a day, the initial dose should be given 6-10 hours after undergoing surgery as long as the hemostatic condition has been established.

The duration of therapy of major pelvic surgery 5 weeks, major knee surgery 2 weeks. Reduces the risk of systemic embolic stroke in patients with nonvalvular atrial fibrillation : 20 mg once a day which is also the recommended maximum dose.

Treatment of DVT where the duration of therapy depends on the disease that causes the initial dose of 15 mg 2 times a day the first 3 weeks then 20 mg once a day.

Xarelto Side Effects

Xarelto side effects that may occur during the usage, namely:

  • Postprocedural bleeding (including postoperative anemia and wound bleeding).
  • Bruise.
  • Fever
  • Peripheral edema.
  • Fatigue.
  • Gastrointestinal bleeding.
  • Abdominal pain.
  • Dyspepsia or abdominal pain in the upper part.
  • Nauseous.
  • Constipation, diarrhea, vomiting.
  • Anemia.
  • Dizzy.
  • Headache.
  • Renal impairment (including an increase in creatinine / blood urea).


Avoid the use of Xarelto in patients who have indications:

  • Hypersensitivity or allergies.
  • Active bleeding, liver diseases associated with coagulopathy and liver cirrhosis patients.
  • Conditions with a significant risk of major bleeding for example, recent GI ulcerations.
  • Spinal or brain injury/surgery.
  • Concomitant treatment with oral anticoagulants, and derivatives of heparin.
  • Pregnant and lactating females.

Drug Interactions

Here are some of the drug interactions that generally occur when using Xarelto:

  • An average increase in AUC with ketoconazole, ritonavir, itraconazole, voriconazole, posaconazole, HIV protease inhibitors.
  • Increased risk of bleeding with other anticoagulants, Non-Steroidal Anti-Inflammatory (AINS).
  • Reduces the average AUC with rifampicin.
  • Plasma concentrations can be reduced by CYP3A4 inducers e.g., phenytoin, carbamazepine, phenobarbital, or St. John’s wort.

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Last Updated on June 12, 2022 Reviewed by Market Health Beauty Team