Hydralazine side effects
Hydralazine side effects (Illustration/Fvasconcellos [Public domain])

Hydralazine side effects, Usage, and Dosage

What are the side effects of Hydralazine? In this article, we will discuss about What is Hydralazine for? How to use dihydralazine? How does Hydralazine work? Packaging and Preparation, Before using the hydralazine, Dosage, Safety Of Use In Pregnant Women, and Hydralazine side effects.

What is Hydralazine for?

Hydralazine is a medicine that is used with or without other treatments to overcome high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Hydralazine is called a vasodilator. This medication works by relaxing blood vessels, so blood can flow into the body more easily.

Other Uses: this section contains uses of these drugs that are not listed in the approved label, but may only be prescribed by your health professional. Use this medication for the condition listed below only if it is prescribed by Your doctor and health expert.

Hydralazine may also be used with other treatments to address heart failure.

How to use dihydralazine?

Take this medication by mouth with or without food as directed by your doctor. The dosage is based on your medical condition and response to treatment. Your doctor may start You with a low dose and gradually increase Your dose. Follow the doctor’s instructions carefully.

Use this medication regularly to get the most optimal. You need to remember, taking the medication at the same time every day. It is important to continue to take this medicine even if you feel well. Most people with high blood pressure do not feel sick. It can take up to several weeks before you get the full benefit of this drug.

How does Hydralazine work?

Hydralazine works by causing the muscles lining and surrounding arteries become relaxed, resulting in widening and lowering blood pressure. While the exact details of how the hydralazine causes relaxation is not known, it is believed that hydralazine interfere with transfer of calcium inside muscle cells.

Because the muscles cannot contract without calcium, these disorders produce muscle relaxation. Along with this relaxing, hydralazine also causes increased heart rate and increased the total amount of blood being pumped by the heart. Hydralazine is officially known as the vasodilator work directly, which means that this drug works directly on blood vessels to itself to cause relaxation.

Packaging and Preparation.

  • Solution, injection, as hydrochloride: 20 mg/mL (1mL).
  • Oral tablet, as hydrochloride: 10 mg, 25 mg, 50 mg, 100 mg.

Before using the hydralazine.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell Your health care professional if you are taking any prescription drugs or other nonprescription (over-the-counter [OTC]) medicine.


  • Use in combination with with Isosorbide.
  • Initial dose: 10-25 mg through the mouth (per oral) 3-4 times a day.
  • If acceptable, upgrade to maintenance Dose: 75 mg through the mouth (per oral), 4 times a day.
  • Maximum Dose: 300-600 mg/day

Safety Of Use In Pregnant Women.

These drugs belong to the C pregnancy risk category (C = may be at risk) according to the US Food and Drugs Administration (FDA).

Hydralazine Side effects:

The following is a list of Hydralazine side effects that can occur in allowing medicines containing it. This is not a comprehensive list. These side effects are possible, but it is not always the case. Some of these side effects are rare but serious. Consultation with your doctor if you notice any side effects, especially if the side effects don’t disappear.

  • Tachycardia
  • Flutter,
  • Palpitations,
  • Facial flushing,
  • Hypotension,
  • Fluid retention,
  • gastrointestinal disorders,
  • Headache,
  • Dizziness,
  • Systemic syndromes such as systemic lupus erythematosus after doses of more than 100 mg per day (or with lower doses in women and individuals with slow acetylator);
  • Symptoms of chest pain
  • Increased heart rate


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  • Skin redness,
  • Fever,
  • Peripheral neuritis,
  • Polineuritis,
  • Artralgia,
  • Paresthesia,
  • Myalgia,
  • Increased lacrimation,
  • Nasal congestion,
  • Dispnea,
  • Agitation,
  • Anorexia,
  • Anxiety;
  • There are reports of blood disorders (including leukopenia, thrombocytopenia, hemolytic anemia),
  • Jaundice,
  • Liver function abnormality,
  • Increased plasma creatinine,
  • Proteinuria, and
  • Hematuria.

If you notice other side effects not listed above, contact your doctor for medical advice. You can also report side effects to your local food and drug administration authority.

Read also: Methadone side effects.

Thank you very much for reading Hydralazine side effects, hopefully useful.

Last Updated on February 23, 2022 Reviewed by Market Health Beauty Team

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