Is Arthritis Hereditary? Many people believe rheumatoid arthritis arthritis is caused by genetic / hereditary factors. Is it true?
For people with rheumatoid arthritis or rheumatism, surely know how torturous this disease is. Because, when relapsed, this arthritis disease can cause the joints to feel pain, swelling, and stiffness. In fact, rheumatoid arthritis can also cause sufferers have difficulty doing simple daily activities, such as writing, opening bottles, wearing clothes and carrying goods.
What is Rheumatoid arthritis?
Rheumatoid Arthritis is inflammation of the joints caused by an autoimmune condition, in which the immune system attacks its own tissues. Rheumatoid arthritis is also referred to as “parental disease” because it is more common among people between the age of 40 and 60, especially women.
Rheumatoid arthritis is a chronic disease that can attack the joints and cause inflammation, swelling, stiffness, pain, to impaired mobility function. These diseases include autoimmune diseases, in which the body forms an excessive immune system and attacks itself.
The most commonly affected are the joints of the hands and feet. If left unchecked, rheumatoid arthritis can cause cartilage destruction and total joint damage. It can also attack other parts of the body, such as the eyes, skin, heart, lungs, and so on.
Is Arthritis Hereditary?
Yes, studies show that genetic factors contribute to the onset of rheumatism.
In principle, this disease fall into the category of multifactorial disorders.
Rheumatic diseases are one of the autoimmune diseases, which is a category of disease in which the body, abnormally, forms an excessive immune response to cells and tissues that are indeed normally in the body itself.
In short, the body builds a system of defense that attacks itself. In line with this, studies show that genetic factors that contribute to the onset of autoimmune diseases are genetic factors that play a role in the immune system.
There are various kinds of Rheumatic diseases, including rheumatoid arthritis, systemic lupus erythematosus (SLE), ankylosing spondilitis, osteoarthritis and osteoporosis. In many ways, almost all types of rheumatic diseases have the same genetic factors.
Types of Lupus That Need To Be Known
The first genetic factor is Major Histocompatibility Complex (MHC) or also called human leukocyte antigen (HLA) encoded by the genes found on chromosome 6. The mechanism behind MHC/HLA’s contribution to rheumatic diseases remains a mystery, although there are already several theories being put forward.
Outside of MHC/HLA-related genes, there is also PTPN22 located within chromosome 1. This gene is tasked with coding an enzyme that plays a role in the regulation of T lymphocytes.
In addition, genetic factors related to B lymphocyte cells tasked with regulating humoral immune responses (which produce antibodies to recognize free antigens) were also found to be associated with rheumatic diseases.
About 53 to 68 percent of rheumatic diseases occur due to family history factors. Some experts mention this because there are certain genes that can increase the risk of rheumatism causing the likelihood of becoming an inherited disease. Thus, it is possible that rheumatism could be inherited in the family line.
A study reported that people who had rheumatism were at risk three times more likely to be exposed to rheumatism usually than the first generation. For example, if your parents have rheumatism, then you or your siblings are at risk of developing rheumatism as a congenital of your parents.
This is also true in twins. Because, identical twins certainly have genes that are almost identical in both. So, there is a 15 percent chance that the twins are also more likely to experience rheumatism if one of the identical twins has rheumatism,. While in twins are not identical, the likelihood of rheumatic development is only 4 percent.
But according to Very Well Health, a person who has a parent with a disease condition that can cause arthritis, not always the next offspring experience a similar condition. However, the family line of arthritis sufferers suffers from a similar condition.
It’s not just genetic factors or family history, there are several other trigger factors that can cause you to have diseases that cause arthritis. Among them are factors of age, gender, environment, lifestyle, obesity, infection of one part of the body, and smo**king habits.
These trigger factors increase the risk if you have a family history with a disease condition that can cause arthritis. If you have a family history with arthritis, always pay attention to a healthy lifestyle and diet in order to avoid the risk of arthritis.
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