Doxycycline Side Effects, and Dosage – Doxycycline is an antibiotic drug used to treat various diseases due to bacterial infections. The drug is also used to overcome acne and prevent malaria. The drug is available in the form of tablets and capsules.
Doxycycline can overcome a variety of diseases due to bacterial infections, ranging from bacterial infections in the lungs, gastrointestinal tract, urinary tract, eyes, skin, to se**xually transmited infections (STIS), such as syphilis. The drug can also be an option to overcome and prevent anthrax.
Doxycycline works by inhibiting and stopping the growth of infection-causing bacteria. Please note, this drug is not effective for treating diseases caused by viral infections, such as colds.
Typically, older person’s dose:
200 mg on the first day (administered as a single dose or 100 mg every 12 hours) followed by a maintenance dose of 100 mg/day (administered as a single dose or as a dose of 50 mg every 12 hours). To cope with more severe infections (especially chronic urinary tract infections), 200 mg daily during the therapy period.
Children over 8 years:
The recommended dose in weights less than or equal to 45 kg is 4.4 mg/kg bw (as a single dose or a two-parted dose on the first day), followed by 2.2 mg/kg bw (single dose or two-split dose) on consecutive days. In more severe infections, it can be up to 4.4 kg/bw. Children weighing more than 45 kg: equal to the older person’s dose.
CHILDREN: Underweight 45 kg: 2.2 mg/kg bw
Oral, twice daily for 60 days. BW more than or equal to 45 kg is equal to the older person’s dose.
- 50-100 mg per day for up to 12 weeks.
Uncomplicated gonococcal infection of the cervix, rectum or urethra where the gonococcus is still sensitive:
Oral doxycycline 100 mg twice a day for 7 days is recommended coupled with the appropriate cephalosporins or quinine, as follows: oral Cefixime 400 mg in a single dose or ceftriaxone 125 mg intramuscularly in a single dose or oral ciprofloxacin 500 mg in a single dose or oral ofloxacin 400 mg in a single dose.
Uncomplicated gonococcal infection of the pharynx, where the gonococcus is still sensitive:
Oral doxycycline 100 mg twice a day for 7 days, it is recommended coupled with appropriate cephalosporins or quinolone, as follows: ceftriaxone 125 mg intramuscularly in a single dose or oral ciprofloxacin 500 mg in a single dose or oral ofloxacin 400 mg in a single dose.
Typhoid or recurrent fever spread by ticks
It can be treated with a single oral dose of 100 or 200 mg, depending on the severity.
Alternative therapy to reduce the risk of unresolved or recurrent fever spread by ticks, recommended doxycycline 100 mg every 12 hours for 7 days.
Early Lyme disease (Phase 1 and 2):
Oral doxycycline 100 mg twice a day for 14-60 days, depending on clinical symptoms and response.
How To Cure Lyme Disease
Rectal, endocervical and urethra infections without complications,
- In older persons caused by chlamydia trachomatis: Oral, 100 mg, twice a day for seven days.
Acute epididymo-orchitis caused by Chlamydia trachomatis or Neisseria gonorrhoeae: ceftriaxone 250 mg IM or other appropriate cephalosporins in a single dose, plus oral doxycycline 100 mg twice a day for 10 days.
Non gonococcal urethritis (NGU)
Non gonococcal urethritis (NGU) caused by Chlamydia trachomatis or Ureaplasma urealyticum: oral, 100 mg, twice a day for seven days.
Primary and secondary syphilis:
Penicillin allergy patients who are not pregnant and suffer from primary or secondary syphilis can be treated with the following regimen: oral doxycycline 100 mg twice a day for two weeks, as an alternative to penicillin therapy.
Latent and tertiary syphilis:
Patients with penicillin allergies who are not pregnant and suffer from secondary or tertiary syphilis can be treated with the following regimen: oral doxycycline 100 mg twice a day for two weeks, as an alternative to penicillin therapy if the duration of infection is known to be less than a year. Otherwise, doxycycline should be administered for four weeks.
Acute pelvic inflammatory disease (PID):
- Inpatient – Doxycycline 100 mg every 12 hours, plus cefoxitin 2 g intravenously every six hours or cefoxitin 2 g IV every 12 hours for a minimum of four days and at least 24-48 hours after the condition improves. Then proceed with oral doxycycline 100 mg twice a day to complete the total therapy for 14 days.
- Outpatient – Oral doxycycline 100 mg twice a day for 14 days as additional therapy on ceftriaxone 250 mg intramuscular once a day or cefoxitin 2 g intramuscularly, plus oral probenecid 1 g single dose taken simultaneously, or injection of other third-generation cephalosporins (eg, ceftizoxime or cefotaxime).
Chloroquine-resistant falciparum malaria treatment:
200 mg per day for at least seven days. Due to the potential for increasingly severe infections, a fast-working schizonticide such as quinine should be administered in combination with doxycycline, the recommended dose of quinine varies in different areas.
For malaria prophylaxis:
- Older persons, 100 mg per day;
- Children over 8 years, 2 mg /kg bw administered once a day, can be up to an older person’s dose.
Prophylaxis can begin at 1-2 days before the journey to the malaria pandemic area. Continued there and four weeks after leaving the area.
lymphogranuloma venereum (lgv) caused by chlamydia trachomatis: oral doxycycline 100 mg twice a day for a minimum of 21 days.
Cholera selective therapy and prophylaxis
Cholera selective therapy and prophylaxis: Older persons, 300 mg single dose.
Prevention of scrub typhus
Prevention of scrub typhus: Oral, 200 mg as a single dose.
Prevention of traveler’s diarrhea:
Older persons, 200 mg on the first day of travel (administered as a single dose or 100 mg every 12 hours) followed by 100 mg daily during the stay in the area. Use above 21 days for prophylactic purposes is not yet available.
Prevention of leptospirosis:
Oral, 200 mg every week during stay in risky areas and 200 mg at the end of the trip. The use of above 21 days for prophylactic purposes is not yet known for its effectiveness.
Leptospirosis therapy: Oral, 100 mg twice a day for 7 days.
Inhalational anthrax (post exposure)
Inhalational anthrax (post exposure): Older persons: Oral doxycycline, 100 mg twice a day for 60 days.
Doxycycline Side Effects
Doxycycline side effects that are quite common are:
- Mild nausea and diarrhea
- Abdominal pain
- Mild itchy skin or rash, or
- Vagi**nal itching or discharge.
Contact your doctor if you experience serious side effects of doxycycline, such as:
- Severe headache, dizziness, blurred vision
- Fever, chills, body aches, flu symptoms, enlarged glands, rash or itching, joint pain, or overall pain
- Less frequent or less urination
- Diarrhea of water or blood
- Pale or yellowing skin, dark urine, fever, confused or weak.
- Severe pain in the upper abdomen radiates to the back, nausea, and vomiting, rapid heart rate
- No appetite, jaundice (yellow skin or eyes) or
- Severe skin reactions – fever, sore throat, swelling of the face or tongue, burning sensation in the eyes, skin pain, followed by a red or purple skin rash that spreads (especially on the face or upper body) and causes the skin to blister and peel off.
Not everyone experiences any of the above side effects after taking doxycycline. There may be some side effects not mentioned above.
If you have concerns about certain side effects after receiving doxycycline, consult your doctor or pharmacist.
Last Updated on April 2, 2021 Reviewed by Market Health Beauty Team